Nobiletin is a polymethoxylated flavone predominantly found in citrus peels. It has attracted attention for multiple bioactivities observed in preclinical models — including antioxidant, anti-inflammatory, and metabolic effects. Researchers study its interactions with signaling pathways such as AMPK and PPARs, as well as its influence on neuroinflammation and synaptic function. While much of the evidence comes from in vitro and animal work, emerging human studies and formulation research are beginning to clarify potential applications and limitations.

• Antioxidant activity Scavenges reactive species and supports cellular redox balance in preclinical models.
• Metabolic regulation Evidence for improved lipid and glucose handling in animal studies.
• Neuroprotective effects Protects against neuroinflammation and supports cognitive function in models.
• Anti-inflammatory action Modulates inflammatory signaling relevant to chronic disease risk.

Ongoing research includes dose-finding, bioavailability enhancement, and early-phase clinical trials. Formulation (e.g., concentrated extracts, nanoparticle delivery) significantly affects bioactivity and human translational potential.

Research Highlights

Browse study summaries, method notes, and expert commentaries to evaluate the quality of evidence and potential next steps for clinical research.